Medicines Formulary - Chapter 8.3: Sex hormones and hormone antagonists in malignant disease

Chapters

Drug name	NICE TAs	Comments
Abiraterone tablets	TA259 - Abiraterone for castration-resistant metastatic prostate cancer previously treated with a docetaxel-containing regimen TA387 - Abiraterone for treating metastatic hormone-relapsed prostate cancer before chemotherapy is indicated
Anastrozole tablets	TA112 - Hormonal therapies for the adjuvant treatment of early oestrogen-receptor-positive breast cancer
Apalutamide	TA741 - Apalutamide with androgen deprivation therapy for treating hormone-sensitive metastatic prostate cancer TA740 - Apalutamide with androgen deprivation therapy for treating high-risk hormone-relapsed non-metastatic prostate cancer
Bicalutamide tablets
Buserelin nasal spray
Cyproterone tablets
Darolutamide (Nubeqa®)	TA660 - Darolutamide with androgen deprivation therapy for treating hormone-relapsed non-metastatic prostate cancer TA903 - Darolutamide with androgen deprivation therapy and docetaxel for treating hormone-sensitive metastatic prostate cancer
Degarelix injection	TA404 - Degarelix for treating advanced hormone-dependent prostate cancer	Supported by ESCA
Diethylstilbestrol tablets		Extremely high relative cost
Enzalutamide capsules	TA316 - Enzalutamide for metastatic hormone-relapsed prostate cancer previously treated with a docetaxel-containing regimen TA712 - Enzalutamide for treating hormone-sensitive metastatic prostate cancer	For hospital use only
Exemestane tablets	TA112 - Hormonal therapies for the adjuvant treatment of early oestrogen-receptor-positive breast cancer
Flutamide tablets
Goserelin implant
Lanreotide (Somatuline Autogel®)		Amber - palliative care use only Red - oncology, acromegaly
Lanreotide (Somatuline® LA)		Amber - palliative care use only Red - oncology, acromegaly
Letrozole tablets	TA112 - Hormonal therapies for the adjuvant treatment of early oestrogen-receptor-positive breast cancer
Leuprorelin acetate injection
Medroxyprogesterone acetate tablets		Provera and Climanor
Megestrol acetate tablets
Norithisterone
Octreotide (Sandostatin LAR®) injection		Amber - palliative care use only Red - Oncology, acromegaly
Octreotide injection		Amber - palliative care use only Red - Oncology, acromegaly
Panobinostat	TA380 - Panobinostat for treating multiple myeloma after at least 2 previous treatments
Tamixofen tablets
Triptorelin (Decapeptyl® SR)

Drug status key

Formulary drugs are allocated a traffic light status. This provides guidance on where clinical and prescribing responsibilities lie in regard to the initiation and maintenance of prescribing.

Grey

Positive NICE TA and/or awaiting local clarification on place in therapy. Please contact your medicines optimisation team for more information.

Red

Initiation and maintenance of prescribing by specialists only.

Amber

Initiation and maintenance of prescribing by specialists and transfer to primary care prescribing when appropriate, or in primary care following a specialists recommendation. Prior to initiation some medicines may require committee agreement or a framework to support safe transfer and maintenance.

Green

Initiation and maintenance of prescribing by specialists, GPs and other qualified clinicians.

Blue

Under review at University Hospitals Birmingham NHS Foundation Trust.